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LGD 4033 was developed with the goal of preventing muscle loss in the elderly and in those who suffer from muscle dystrophy, an incurable genetic disorder in which muscles atrophy and become weaker. The drug works by blocking two genes known as MAFB1 and MAF2, which are linked to the muscle contraction and also cause muscle wasting.
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Researchers from the NIH reported receiving regulatory approval for a trial starting this summer for treatment of rheumatoid arthritis. The trial will begin in August and includes patients with rheumatoid arthritis and will test MOMA-C 4033 as part of the study.
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